Sero-conversion of HCV infection at Governmental haemodialysis units among isolated and non isolated patients, 2007- 2009, Egypt.

Background :Egypt is facing an epidemic of hepatitis C virus (HCV). The prevalence is 14.7%. Hemodialysis. (HD) patients are at increased risk for nosocomial infection. The isolation of HCV patients in hemodialysis (HD) units has been repeatedly advocated. We investigated the effect of isolation of HD patients on the incidence of seroconversion. Methods: A retrospective cohort study was conducted in 24 dialysis units. 12 units were implementing isolation (UII) and 12 units with no isolation (UNI). A multi stage random sampling was conducted to select a sample of sero-negative patients representing each group. Medical records of all HD patients from 2007-2009 were reviewed. Personal interviews for available patients were conducted using a standardized questionnaire that included demographic data, period and frequency of renal analysis, risk factors for acquiring HCV and date of sero-conversion. Results: 1774 sero-negative patients were enrolled, including 865 (48.7%) patients in UII , and 909 (51.3%) patients in UNI. Sero-conversion rate in the UNI was significantly higher 72(8%), compared to 19 (2%) in UII (p <0.01). The median age of sero-converted patients was 50 years (range 19-73), with slight male preponderance. Conclusions: Higher sero-conversion rates were identified in HD units. Isolation for HCV patients in HD units significantly reduced the sero-conversion rate. Enforcing adherence to universal precautions is essential for reducing transmission of HCV in these settings. Key words: HCV, incidence, hemodialysis , Egypt For more information, email the presenter at:

Author (s): 

Khaled Hassanein1, Amr Kandeel2, Mohamed Abdel Fattah1, Samar Abdel Sattar1, Eman Abd Elkereem1,3 Field Epidemiology Training Program, Egypt Ministry of Health, 2Communicable Disease Departement, Egypt Ministry of health. 3Epidemiology and Surveillanc

Presenter (s): 
Dr. Mohamed Abd Elfatah
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