Short-course Zidovudine Compared to What? A Trial to Prevent Mother-to-Infant HIV Transmission

Ethical and scientific issues associated with a randomized controlled trial of zidovudine to prevent mother-to-child transmission of HIV in developing countries after its effectiveness had been established in developed countries.

 

Objectives

  • Discuss the principle of equipoise and its relevance in designating an appropriate comparison group in a randomized controlled trial (RCT)
  • Describe the role of an Institutional Review Board
  • List the required elements of informed consent and discuss key considerations in using informed consent in developing countries
  • Describe the ethical rationale for conducting an interim analysis of a clinical trial

 

Investigation: 
Other
Year: 
2012
Author (s): 

Richard Dicker

Dana Schneider

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