Vaccine efficacy

A Measles Outbreak in a Highly Vaccinated Population (“Measles in Burundi”)

An outbreak of measles occurred in health sector Muyinga (Burundi), several years into an apparently successful vaccination program.  This case study addresses estimation of vaccine coverage and vaccine efficacy in the field.

 

Objectives:

  • Discuss methods for estimating vaccination coverage;
  • Describe the difference between a convenience sample and a probability sample;
  • Describe the sampling method used in WHO-EPI surveys; and
  • Calculate and interpret vaccine efficacy.
Investigation: 
Outbreak
Country: 
Burundi
Year: 
1991
Author (s): 

Robert Chen, Bernard Morniere and Richard Dicker

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Epidemic Measles in a Divided City ("Texarkana")

Measles outbreak in a community on the border of two states — the Arkansas side with required school immunization and high immunization rates, the Texas side without required immunization and low immunized rates, 1970.

Objectives

•    Discuss the advantages and disadvantages of using a sensitive and/or specific case definition in an epidemic investigation;

•    Calculate vaccine efficacy and discuss its interpretation; and

Investigation: 
Outbreak
Country: 
United States
Year: 
1971
Author (s): 

 Philip Landrigan, Lyle Conrad and John Witte

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